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Engineering Yeast for Producing Human Glycoproteins: Where are We Now?

1 Jan 2015

Abstract excerpt

Yeast has advanced as an alternative for mammalian cell culture for the production of recombinant therapeutic glycoproteins. Engineered yeast strains not only allow to mimic the human N-glycosylation pathway but also specific types of human O-glycosylation. This is of great value for therapeutic protein production and indispensable to determine the structure-function relationships of glycans on recombinant...

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PMID: 25598335
DOI: 10.2217/fmb.14.104

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