Article
East Asian variant aldehyde dehydrogenase type 2 genotype exacerbates ischemia/reperfusion injury with ST-elevation myocardial infarction in men: possible sex differences.
Heart and vessels - 1 Feb 2022
Ishida Toshifumi, Arima Yuichiro, Mizuno Yuji, Harada Eisaku, Yamashita Takayoshi, Sueta Daisuke, Sakamoto Kenji, Suzuki Satoru, Kaikita Koichi, Yamada Yoshihiro, Shimomura Hideki, Oniki Kentaro, Saruwatari Junji, Hokimoto Seiji, Yasue Hirofumi, Tsujita Kenichi
Abstract excerpt
Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies toxic aldehydes generated during ischemia/reperfusion (I/R) injury in ST-elevation myocardial infarction (STEMI). The deficient variant ALDH2 genotype (ALDH2*2) is prevalent among East Asians. Whether ALDH2*2 exacerbates I/R injury of in patients with STEMI is not known. The study subjects comprised 218 Japanese patients with STEMI (158 men and 60 women,...
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