Article
Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome.
Journal of cellular and molecular medicine - 1 Sept 2011
Xu Feng, Chen Yu Guo, Xue Li, Li Rui Jian, Zhang He, Bian Yuan, Zhang Cheng, Lv Rui Juan, Feng Jin Bo, Zhang Yun
Abstract excerpt
This study aimed to investigate the association of the aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism, which exists in 30-50% of East Asians, and risk of acute coronary syndrome (ACS). We enrolled 1092 unrelated Han Chinese, including 546 with ACS and 546 age- and sex-matched controls. Subjects with ALDH2 mutant genotypes showed significantly higher ACS than did controls (46.7% versus 31.9%, P < 0.001)....
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