Article
Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Sept 2002
Takagi Shuichi, Iwai Naoharu, Yamauchi Ryoko, Kojima Sunao, Yasuno Shinji, Baba Takeshi, Terashima Masahiro, Tsutsumi Yoshiaki, Suzuki Shoji, Morii Isao, Hanai Sotaro, Ono Koh, Baba Shunroku, Tomoike Hitonobu, Kawamura Atsushi, Miyazaki Shunichi, Nonogi Hiroshi, Goto Yoichi
Abstract excerpt
In epidemiological studies, moderate alcohol consumption has been consistently associated with a reduced risk of myocardial infarction (MI). About half of Japanese show an extremely high sensitivity to alcohol (ethanol), which is due to a missense mutation from glutamic acid (Glu) to lysine (Lys) at codon 487 in an isoenzyme of aldehyde dehydrogenase (ALDH2) with a low Km. We obtained a preliminary result that...
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