Article
Combined effects of current-smoking and the aldehyde dehydrogenase 2*2 allele on the risk of myocardial infarction in Japanese patients.
Toxicology letters - 5 Jan 2015
Morita Kazunori, Miyazaki Hiroko, Saruwatari Junji, Oniki Kentaro, Kumagae Naoki, Tanaka Takahiro, Kajiwara Ayami, Otake Koji, Ogata Yasuhiro, Arima Yuichiro, Hokimoto Seiji, Ogawa Hisao, Nakagawa Kazuko
Abstract excerpt
Aldehyde dehydrogenase 2 (ALDH2) detoxifies toxic aldehydes, e.g. acetaldehyde in cigarette smoke; however, the interactive effects between smoking status and the ALDH2 genotype on coronary artery disease (CAD) have not been reported. We investigated the effects of smoking status and the ALDH2 genotype, and assessed their interactive and combined effects on the risk of myocardial infarction (MI) or stable angina...
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