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Article

Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.

PloS one - 1 Jan 2013

Kelkka Tiina, Pizzolla Angela, Laurila Juha Petteri, Friman Tomas, Gustafsson Renata, Källberg Eva, Olsson Olof, Leanderson Tomas, Rubin Kristofer, Salmi Marko, Jalkanen Sirpa, Holmdahl Rikard

Abstract excerpt

The NADPH oxidase 2 (NOX2) complex is a professional producer of reactive oxygen species (ROS) and is mainly expressed in phagocytes. While the activity of the NOX2 complex is essential for immunity against pathogens and protection against autoimmunity, its role in the development of malignant tumors remains unclear. We compared wild type and Ncf1 (m1J) mutated mice, which lack functional NOX2 complex, in four...

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Source

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Identifiers

PMID: 24358335
DOI: 10.1371/journal.pone.0084148
PMCID: PMC3865299

Genes

NCF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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