Article
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.
Nature - 18 Jun 2015
Coffelt Seth B, Kersten Kelly, Doornebal Chris W, Weiden Jorieke, Vrijland Kim, Hau Cheei-Sing, Verstegen Niels J M, Ciampricotti Metamia, Hawinkels Lukas J A C, Jonkers Jos, de Visser Karin E
Abstract excerpt
Metastatic disease remains the primary cause of death for patients with breast cancer. The different steps of the metastatic cascade rely on reciprocal interactions between cancer cells and their microenvironment. Within this local microenvironment and in distant organs, immune cells and their mediators are known to facilitate metastasis formation. However, the precise contribution of tumour-induced systemic...
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