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Article

A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Sept 2017

Olsson Lina M, Johansson Åsa C, Gullstrand Birgitta, Jönsen Andreas, Saevarsdottir Saedis, Rönnblom Lars, Leonard Dag, Wetterö Jonas, Sjöwall Christopher, Svenungsson Elisabet, Gunnarsson Iva, Bengtsson Anders A, Holmdahl Rikard

Abstract excerpt

OBJECTIVES: Ncf1 polymorphisms leading to low production of reactive oxygen species (ROS) are strongly associated with autoimmune diseases in animal models. The human NCF1 gene is very complex with both functional and non-functional gene copies and genotyping requires assays specific for functional NCF1 genes. We aimed at investigating association and function of the missense single nucleotide polymorphism (SNP),...

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Identifiers

PMID: 28606963
DOI: 10.1136/annrheumdis-2017-211287

Genes

NCF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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