Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density.

The Journal of clinical endocrinology and metabolism - 21 Oct 2021

Schmitz Daniel, Ek Weronica E, Berggren Elin, Höglund Julia, Karlsson Torgny, Johansson Åsa

Abstract excerpt

CONTEXT: Estradiol is the primary female sex hormone and plays an important role for skeletal health in both sexes. Several enzymes are involved in estradiol metabolism, but few genome-wide association studies (GWAS) have been performed to characterize the genetic contribution to variation in estrogen levels. OBJECTIVE: Identify genetic loci affecting estradiol levels and estimate causal effect of estradiol on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Share to ABO Blood-Group System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bone Density

Share to Cytochrome P-450 CYP3A

Share to Estradiol

Share to Estrogens

Share to Glucuronosyltransferase

Share to N-Acetylglucosaminyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 34255042
DOI: 10.1210/clinem/dgab507
PMCID: PMC8530739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density.PMID 34255042Read ↗

Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in men.Semantic proximity Read ↗

Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.Semantic proximity Read ↗

Cross-ancestry Genome-wide Association Studies of Sex Hormone Concentrations in Pre- and Postmenopausal WomenSemantic proximity Read ↗

Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study.Semantic proximity Read ↗

Genetic analyses on the health impacts of testosterone highlight effects on female-specific diseases and sex differencesSemantic proximity Read ↗

Genetic analyses implicate complex links between adult testosterone levels and health and diseaseSemantic proximity Read ↗

Using human genetics to understand the disease impacts of testosterone in men and women.Semantic proximity Read ↗

Sex hormones regulate lipid metabolism in adult Sertoli cells: A genome-wide study of estrogen and androgen receptor binding sitesSemantic proximity Read ↗

Estrogen-related genes and postmenopausal osteoporosis risk.Semantic proximity Read ↗

Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes.Semantic proximity Read ↗

Genetically Predicted Sex Hormone-Binding Globulin and Bone Mineral Density: A Mendelian Randomization Study.Semantic proximity Read ↗

Metabolomic Pathways to Osteoporosis in Middle-Aged Women: A Genome-Metabolome-Wide Mendelian Randomization StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.