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Cross-ancestry Genome-wide Association Studies of Sex Hormone Concentrations in Pre- and Postmenopausal Women

22 Feb 2022

Abstract excerpt

OBJECTIVE: Concentrations of circulating sex hormones have been associated with a variety of diseases in women and are strongly influenced by menopausal status. We investigated the genetic architectures of circulating concentrations of estradiol, testosterone, and SHBG by menopausal status in women of European and African ancestry. METHODS: Using data on 229 966 women from the UK Biobank, we conducted genome-wide...

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PMID: 35192695
DOI: 10.1210/endocr/bqac020

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