Article
Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.
The Journal of clinical endocrinology and metabolism - 1 Mar 2018
Eriksson Anna L, Perry John R B, Coviello Andrea D, Delgado Graciela E, Ferrucci Luigi, Hoffman Andrew R, Huhtaniemi Ilpo T, Ikram M Arfan, Karlsson Magnus K, Kleber Marcus E, Laughlin Gail A, Liu Yongmei, Lorentzon Mattias, Lunetta Kathryn L, Mellström Dan, Murabito Joanne M, Murray Anna, Nethander Maria, Nielson Carrie M, Prokopenko Inga, Pye Stephen R, Raffel Leslie J, Rivadeneira Fernando, Srikanth Priya, Stolk Lisette, Teumer Alexander, Travison Thomas G, Uitterlinden André G, Vaidya Dhananjay, Vanderschueren Dirk, Zmuda Joseph M, März Winfried, Orwoll Eric S, Ouyang Pamela, Vandenput Liesbeth, Wu Frederick C W, de Jong Frank H, Bhasin Shalender, Kiel Douglas P, Ohlsson Claes
Abstract excerpt
Context: Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability. Objective: To investigate the genetic regulation of serum E2 and E1 in men. Design, Setting, and Participants: Genome-wide association study in 11,097 men of European origin from nine epidemiological cohorts. Main Outcome Measures: Genetic determinants of serum E2 and E1 levels. Results: Variants in/near CYP19A1 demonstrated...
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