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Causal relationships between sex hormone traits, lifestyle factors, and osteoporosis in men: A Mendelian randomization study.

PloS one - 1 Jan 2022

Wang Hui, Cheng Jianwen, Wei Donglei, Wu Hong, Zhao Jinmin

Abstract excerpt

Although observational studies have explored factors that may be associated with osteoporosis, it is not clear whether they are causal. Osteoporosis in men is often underestimated. This study aimed to identify the causal risk factors associated with bone mineral density(BMD) in men. Single nucleotide polymorphisms (SNPs) associated with the exposures at the genome-wide significance (p < 5x10-8) level were...

Topics

Bone Density
Genome-Wide Association Study
Humans
Life Style
Male
Mendelian Randomization Analysis
Osteoporosis
Polymorphism, Single Nucleotide
Testosterone

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PMID: 35925966
DOI: 10.1371/journal.pone.0271898
PMCID: PMC9351993

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