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Article

Tumor DNA Mutations From Intraparenchymal Brain Metastases Are Detectable in CSF.

JCO precision oncology - 1 Jan 2021

Cheok Stephanie Kim, Narayan Azeet, Arnal-Estape Anna, Gettinger Scott, Goldberg Sarah B, Kluger Harriet M, Nguyen Don, Patel Abhijit, Chiang Veronica

Abstract excerpt

Discordant responses between brain metastases and extracranial tumors can arise from branched tumor evolution, underscoring the importance of profiling mutations to optimize therapy. However, the morbidity of brain biopsies limits their use. We investigated whether cell-free DNA (cfDNA) in CSF could serve as an effective surrogate marker for genomic profiling of intraparenchymal (IP) brain metastases. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34250381
DOI: 10.1200/PO.20.00292
PMCID: PMC8232069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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