Article
Unique genetic profiles from cerebrospinal fluid cell-free DNA in leptomeningeal metastases of EGFR-mutant non-small-cell lung cancer: a new medium of liquid biopsy.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2018
Li Y S, Jiang B Y, Yang J J, Zhang X C, Zhang Z, Ye J Y, Zhong W Z, Tu H Y, Chen H J, Wang Z, Xu C R, Wang B C, Du H J, Chuai S, Han-Zhang H, Su J, Zhou Q, Yang X N, Guo W B, Yan H H, Liu Y H, Yan L X, Huang B, Zheng M M, Wu Y L
Abstract excerpt
Background: Leptomeningeal metastases (LM) are more frequent in non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. Due to limited access to leptomeningeal lesions, the purpose of this study was to explore the potential role of cerebrospinal fluid (CSF) as a source of liquid biopsy in patients with LM. Patients and methods: Primary tumor, CSF, and plasma in NSCLC with LM...
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