Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical evaluation of a Hepatitis C Virus whole-genome sequencing pipeline for genotyping and resistance testing.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Mar 2022

Bradshaw Daniel, Bibby David F, Manso Carmen F, Piorkowska Renata, Mohamed Hodan, Ledesma Juan, Bubba Laura, Chan Yuen T, Ngui Siew Lin, Carne Simon, Mbisa Jean L

Abstract excerpt

OBJECTIVES: We sought to evaluate clinically a hepatitis C virus (HCV) whole-genome, next-generation sequencing (NGS) pipeline that is agnostic to viral genotype. METHODS: Performance of the NGS pipeline was assessed through comparison of results with Sanger sequencing (SS) of partial HCV genomes. RESULTS: There was 98.7% (376/381) concordance for viral subtype between SS and NGS. The positive and negative per...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Hepacivirus

Share to Hepatitis C

Share to High-Throughput Nucleotide Sequencing

Source

Identifiers

PMID: 34245902
DOI: 10.1016/j.cmi.2021.06.042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical evaluation of a Hepatitis C Virus whole-genome sequencing pipeline for genotyping and resistance testing.PMID 34245902Read ↗

Technical Validation of a Hepatitis C Virus Whole Genome Sequencing Assay for Detection of Genotype and Antiviral Resistance in the Clinical PathwaySemantic proximity Read ↗

Comparison of Next-Generation Sequencing Technologies for Comprehensive Assessment of Full-Length Hepatitis C Viral Genomes.Semantic proximity Read ↗

Validation of a Genotype-Independent Hepatitis C Virus Near-Whole Genome Sequencing Assay.Semantic proximity Read ↗

Full-genome next-generation sequencing of hepatitis C virus to assess the accuracy of genotyping by the commercial assay LiPA and the prevalence of resistance-associated substitutions in a Belgian cohort.Semantic proximity Read ↗

Whole genome sequencing of hepatitis C virus from dried blood spots by hybrid capture for genotype and antiviral resistance determination.Semantic proximity Read ↗

A near full-length open reading frame next generation sequencing assay for genotyping and identification of resistance-associated variants in hepatitis C virus.Semantic proximity Read ↗

Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus.Semantic proximity Read ↗

Global epidemiology of HCV subtypes and resistance-associated substitutions evaluated by sequencing-based subtype analyses.Semantic proximity Read ↗

Whole genome pyrosequencing of rare hepatitis C virus genotypes enhances subtype classification and identification of naturally occurring drug resistance variants.Semantic proximity Read ↗

Amplification and sequencing of the hepatitis C virus NS3/4A protease and the NS5B polymerase regions for genotypic resistance detection of clinical isolates of subtypes 1a and 1b.Semantic proximity Read ↗

Sequence and phenotypic analysis for resistance monitoring in hepatitis C virus drug development: recommendations from the HCV DRAG.Semantic proximity Read ↗

Genotype- and Subtype-Independent Full-Genome Sequencing Assay for Hepatitis C VirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.