Article
Full-genome next-generation sequencing of hepatitis C virus to assess the accuracy of genotyping by the commercial assay LiPA and the prevalence of resistance-associated substitutions in a Belgian cohort.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Oct 2022
Christensen Kasper T, Pierard Florian, Beuselinck Kurt, Bonsall David, Bowden Rory, Lagrou Katrien, Nevens Frederik, Schrooten Yoeri, Simmonds Peter, Vandamme Anne-Mieke, Van Wijngaerden Eric, Dierckx Tim, Cuypers Lize, Van Laethem Kristel
Abstract excerpt
BACKGROUND: Although most currently used regimens for Hepatitis C virus (HCV) infections can be initiated without prior knowledge of genotype and subtype, genotyping is still useful to identify patients who might benefit from a personalized treatment due to resistance to direct-acting antivirals (DAA). OBJECTIVES: To assess the utility of full-genome next-generation sequencing (FG-NGS) for HCV genotyping. STUDY...
Topics
- Antiviral Agents
- Belgium
- Drug Resistance, Viral
- Genotype
- Hepacivirus
- Hepatitis C
- Hepatitis C, Chronic
- High-Throughput Nucleotide Sequencing