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Article

Polygenic associations and causal inferences between serum immunoglobulins and amyotrophic lateral sclerosis.

Clinica chimica acta; international journal of clinical chemistry - 1 Oct 2021

Chen Xu, Shen Xiaojun, Zhang Xuzhuo, Zhan Yiqiang, Fang Fang

Abstract excerpt

BACKGROUND: Due to the limitations like reverse causation and residual confounding commonly seen in the observational studies, the relationship between serum immunoglobulins and amyotrophic lateral sclerosis (ALS) remains unclear. METHODS: Summary statistics from large-scale genome-wide association studies (GWAS) among European ancestry populations (~15,000 individuals for serum immunoglobulins, and more than...

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PMID: 34245689
DOI: 10.1016/j.cca.2021.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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