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Article

Assessing the role of blood pressure in amyotrophic lateral sclerosis: a Mendelian randomization study.

Orphanet journal of rare diseases - 16 Feb 2022

Xia Kailin, Zhang Linjing, Tang Lu, Huang Tao, Fan Dongsheng

Abstract excerpt

BACKGROUND: Observational studies have suggested a close but controversial relationship between blood pressure (BP) and amyotrophic lateral sclerosis (ALS). It remains unclear whether this association is causal. The authors employed a bidirectional two-sample Mendelian randomization (MR) approach to evaluate the causal relationship between BP and ALS. Genetic proxies for systolic blood pressure (SBP), diastolic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35172853
DOI: 10.1186/s13023-022-02212-0
PMCID: PMC8848798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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