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Article

Polygenic link between blood lipids and amyotrophic lateral sclerosis.

Neurobiology of aging - 1 Jul 2018

Chen Xu, Yazdani Solmaz, Piehl Fredrik, Magnusson Patrik K E, Fang Fang

Abstract excerpt

Dyslipidemia is common among patients with amyotrophic lateral sclerosis (ALS). We aimed to test the association and causality between blood lipids and ALS, using polygenic analyses on the summary results of genome-wide association studies. Polygenic risk scores (PRSs) based on low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) risk alleles were significantly associated with a higher risk of...

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PMID: 29685649
DOI: 10.1016/j.neurobiolaging.2018.03.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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