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Article

Phenome-wide genetic-correlation analysis and genetically informed causal inference of amyotrophic lateral sclerosis.

Human genetics - 1 Aug 2023

D'Antona Salvatore, Pathak Gita A, Koller Dora, Porro Danilo, Cava Claudia, Polimanti Renato

Abstract excerpt

Leveraging genome-wide association statistics generated from a large study of amyotrophic lateral sclerosis (ALS; 29,612 cases and 122,656 controls) and UK Biobank (UKB; 4,024 phenotypes, up to 361,194 participants), we conducted a phenome-wide analysis of ALS genetic liability and identified 46 genetically correlated traits, such as fluid intelligence score (rg = - 0.21, p = 1.74 × 10-6), "spending time in pub...

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Identifiers

PMID: 36773064
DOI: 10.1007/s00439-023-02525-5
PMCID: PMC10449723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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