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Article

Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation.

The American journal of pathology - 1 Oct 2021

Matthews Destiny R, Li Honggui, Zhou Jing, Li Qingsheng, Glaser Shannon, Francis Heather, Alpini Gianfranco, Wu Chaodong

Abstract excerpt

Inflammation drives the pathogenesis of nonalcoholic steatohepatitis (NASH). The current study examined changes in intestinal inflammation during NASH. In male C57BL/6J mice, feeding a methionine- and choline-deficient diet (MCD) resulted in severe hepatic steatosis and inflammation relative to feeding a chow diet (CD). MCD-fed mice exhibited characteristics of mucosal and submucosal inflammatory responses...

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Identifiers

PMID: 34242656
DOI: 10.1016/j.ajpath.2021.06.010
PMCID: PMC8485057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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