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Article

CD18 deficiency improves liver injury in the MCD model of steatohepatitis.

PloS one - 1 Jan 2017

Pierce Andrew A, Duwaerts Caroline C, Siao Kevin, Mattis Aras N, Goodsell Amanda, Baron Jody L, Maher Jacquelyn J

Abstract excerpt

Neutrophils and macrophages are important constituents of the hepatic inflammatory infiltrate in non-alcoholic steatohepatitis. These innate immune cells express CD18, an adhesion molecule that facilitates leukocyte activation. In the context of fatty liver, activation of infiltrated leukocytes is believed to enhance hepatocellular injury. The objective of this study was to determine the degree to which activated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28873429
DOI: 10.1371/journal.pone.0183912
PMCID: PMC5584926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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