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Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling

8 Jul 2021

Abstract excerpt

Glioblastoma (GBM) is a prevalent and highly lethal form of glioma, with rapid tumor progression and frequent recurrence. Excessive outgrowth of pericytes in GBM governs the ecology of the perivascular niche, but their function in mediating chemoresistance has not been fully explored. Herein, we uncovered that pericytes potentiate DNA damage repair (DDR) in GBM cells residing in the perivascular niche, which...

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PMID: 34239070
DOI: 10.1038/s41422-021-00528-3

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