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PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide

2025-02-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Despite multi-model therapy of maximal surgical resection, radiation, chemotherapy, and tumor-treating fields, glioblastoma patients show dismal prognosis. Protein Arginine Methyltransferase 5 (PRMT5) is overexpressed in glioblastoma and its inhibition imparts an anti-tumor effect. Even though Temozolomide (TMZ) is the standard chemotherapeutic agent in the trea...

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Literature Corpus work
7eec9c10-8115-533d-bf56-952254485ec7
DOI
10.21203/rs.3.rs-5936706/v1
Open publication

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PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomideDOI 10.21203/rs.3.rs-5936706/v1
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