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Article

Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production.

JCI insight - 23 Aug 2021

Ke Sujie, Liu Yan-Yun, Karthikraj Rajendiran, Kannan Kurunthachalam, Jiang Jingjing, Abe Kiyomi, Milanesi Anna, Brent Gregory A

Abstract excerpt

Thyroid hormone receptor β (THRB) is posttranslationally modified by small ubiquitin-like modifier (SUMO). We generated a mouse model with a mutation that disrupted sumoylation at lysine 146 (K146Q) and resulted in desumoylated THRB as the predominant form in tissues. The THRB K146Q mutant mice had normal serum thyroxine (T4), markedly elevated serum thyrotropin-stimulating hormone (TSH; 81-fold above control),...

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Identifiers

PMID: 34237030
DOI: 10.1172/jci.insight.149425
PMCID: PMC8410017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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