Article
Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation.
The Journal of biological chemistry - 20 Mar 2015
Liu Yan-Yun, Ayers Stephen, Milanesi Anna, Teng Xiaochun, Rabi Sina, Akiba Ysutada, Brent Gregory A
Abstract excerpt
Thyroid hormone and thyroid hormone receptor (TR) play an essential role in metabolic regulation. However, the role of TR in adipogenesis has not been established. We reported previously that TR sumoylation is essential for TR-mediated gene regulation and that mutation of either of the two sites in TRα or any of the three sites in TRβ reduces TR sumoylation. Here, we transfected TR sumoylation site mutants into...
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