Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired auditory processing and altered structure of the endbulb of Held synapse in mice lacking the GluA3 subunit of AMPA receptors.

Hearing research - 1 Feb 2017

García-Hernández Sofía, Abe Manabu, Sakimura Kenji, Rubio María E

Abstract excerpt

AMPA glutamate receptor complexes with fast kinetics conferred by subunits like GluA3 and GluA4 are essential for temporal precision of synaptic transmission. The specific role of GluA3 in auditory processing and experience related changes in the auditory brainstem remain unknown. We investigated the role of the GluA3 in auditory processing by using wild type (WT) and GluA3 knockout (GluA3-KO) mice. We recorded...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acoustic Stimulation
Share to Auditory Perception

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Behavior, Animal

Share to Evoked Potentials, Auditory, Brain Stem

Share to Hearing

Share to Reaction Time

Share to Receptors, AMPA

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 28011083
DOI: 10.1016/j.heares.2016.12.006
PMCID: PMC5240188

Genes

ABR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired auditory processing and altered structure of the endbulb of Held synapse in mice lacking the GluA3 subunit of AMPA receptors.PMID 28011083Read ↗

VGLUT3-p.A211V variant fuses stereocilia bundle and elongates synaptic ribbons in the human deafness DFNA25Semantic proximity Read ↗

Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.Semantic proximity Read ↗

Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice.Semantic proximity Read ↗

Orphan glutamate receptor delta1 subunit required for high-frequency hearing.Semantic proximity Read ↗

Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem.Semantic proximity Read ↗

Synaptic refinement of an inhibitory topographic map in the auditory brainstem requires functional Cav1.3 calcium channels.Semantic proximity Read ↗

Morphology, GluR1 and GRIP-C localization differ in octopus cells of C57BL6 and B6Cast mice.Semantic proximity Read ↗

The effect of progressive hearing loss on the morphology of endbulbs of Held and bushy cells.Semantic proximity Read ↗

Beyond Excitotoxicity: Glutamate-Independent Mechanisms Underlie Noise-Induced Synaptopathy and Compromise Gene Therapy for Hereditary DeafnessSemantic proximity Read ↗

Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex.Semantic proximity Read ↗

Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss.Semantic proximity Read ↗

Gating of hair cell Ca <sup>2+</sup> channels governs the activity of cochlear neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.