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Article

Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype.

Journal of experimental & clinical cancer research : CR - 7 Jul 2021

Chernyakov Dmitry, Groß Alexander, Fischer Annika, Bornkessel Nicola, Schultheiss Christoph, Gerloff Dennis, Edemir Bayram

Abstract excerpt

BACKGROUND: Renal cell carcinomas (RCC) are characterized by the deregulation of several hundred hyperosmolality-responsive genes. High expression of a subset of these genes including the Ran binding protein 3 like (RANBP3L) is linked to a favorable prognostic outcome in RCC. However, the cellular function of RANBP3L remains largely unknown. METHODS: We used CRISPR/Cas9-mediated gene editing to generate...

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Identifiers

PMID: 34233711
DOI: 10.1186/s13046-021-01982-y
PMCID: PMC8265145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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