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Article

Tumor-specific isoform switch of the fibroblast growth factor receptor 2 underlies the mesenchymal and malignant phenotypes of clear cell renal cell carcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2013

Zhao Qi, Caballero Otavia L, Davis Ian D, Jonasch Eric, Tamboli Pheroze, Yung W K Alfred, Weinstein John N, Strausberg Robert L, Yao Jun

Abstract excerpt

PURPOSE: We aim to identify tumor-specific alternative splicing events having potential applications in the early detection, diagnosis, prognosis, and therapy for cancers. EXPERIMENTAL DESIGN: We analyzed RNA-seq data on 470 clear cell renal cell carcinomas (ccRCC) and 68 kidney tissues to identify tumor-specific alternative splicing events. We further focused on the fibroblast growth factor receptor 2 (FGFR2)...

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Share to Alternative Splicing
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Neoplasms

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Share to Protein Isoforms

Share to Receptor, Fibroblast Growth Factor, Type 2

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Share to Sequence Analysis, RNA

Source

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Identifiers

PMID: 23444225
DOI: 10.1158/1078-0432.CCR-12-3708
PMCID: PMC3644028

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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