Article
[Molecular mechanisms of angioimmunoblastic T-cell lymphoma].
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Mar 2015
Sakata-Yanagimoto Mamiko
Abstract excerpt
Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma. The origins of AITL tumor cells were thought to be follicular helper T (TFH) cells based on the common features of these two cell types. Recent findings suggest a multistep model for the development of AITL. The immature blood cells evolve into premalignant (prelymphoma) cells by acquisition of premalignant mutations...
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