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Article

Review of the biologic and clinical significance of genetic mutations in angioimmunoblastic T-cell lymphoma.

Cancer science - 1 Mar 2018

Fukumoto Kota, Nguyen Tran B, Chiba Shigeru, Sakata-Yanagimoto Mamiko

Abstract excerpt

Angioimmunoblastic T-cell lymphoma (AITL) is an age-related malignant lymphoma, characterized by immune system-dysregulated symptoms. Recent sequencing studies have clarified the recurrent mutations in ras homology family member A (RHOA) and in genes encoding epigenetic regulators, tet methyl cytosine dioxygenase 2 (TET2), DNA methyl transferase 3 alpha (DNMT3A) and isocitrate dehydrogenase 2, mitochondrial...

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Share to Dioxygenases
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, T-Cell

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Source

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Identifiers

PMID: 28889481
DOI: 10.1111/cas.13393
PMCID: PMC5834775

Genes

IDH2
RHOA
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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