Article
Herpes Simplex Virus 1 UL34 Protein Regulates the Global Architecture of the Endoplasmic Reticulum in Infected Cells.
Journal of virology - 15 Jun 2017
Maeda Fumio, Arii Jun, Hirohata Yoshitaka, Maruzuru Yuhei, Koyanagi Naoto, Kato Akihisa, Kawaguchi Yasushi
Abstract excerpt
Upon herpes simplex virus 1 (HSV-1) infection, the CD98 heavy chain (CD98hc) is redistributed around the nuclear membrane (NM), where it promotes viral de-envelopment during the nuclear egress of nucleocapsids. In this study, we attempted to identify the factor(s) involved in CD98hc accumulation and demonstrated the following: (i) the null mutation of HSV-1 UL34 caused specific dispersion throughout the cytoplasm...
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