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Article

Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation.

The Journal of biological chemistry - 13 Jan 2006

Arévalo Juan Carlos, Pereira Daniela B, Yano Hiroko, Teng Kenneth K, Chao Moses V

Abstract excerpt

Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, activate Trk receptor tyrosine kinases through receptor dimerization at the cell surface followed by autophosphorylation and recruitment of intracellular signaling molecules. The intracellular pathways used by neurotrophins share many common protein substrates that are used by other receptor tyrosine kinases (RTK), such as Shc,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16284401
DOI: 10.1074/jbc.M504163200

Genes

FRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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