Does the 2-test in vitro genotoxicity battery of Ames plus in vitro micronucleus tests detect relevant substances that induce gene mutations in vivo?

doi:10.1016/j.mrgentox.2026.503949

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Article

Does the 2-test in vitro genotoxicity battery of Ames plus in vitro micronucleus tests detect relevant substances that induce gene mutations in vivo?

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jul 2026

Kirkland David, Bowen Damian, Fowler Paul

Abstract excerpt

The in vitro genotoxicity testing battery comprising a bacterial gene mutation test (Ames test) and an in vitro micronucleus (MNvit) test is widely recommended by regulatory authorities since it detects the 3 key modes of genotoxic action (gene mutations, clastogenicity and aneuploidy). The recommendations that this battery is acceptable for regulatory use are based on its ability to effectively detect in vivo...

Topics

Animals
Humans
DNA Damage
Micronucleus Tests
Mutagenicity Tests
Mutagens
Mutation
Membrane Proteins

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Open in PubMed

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PMID: 42580787
DOI: 10.1016/j.mrgentox.2026.503949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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