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Article

Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal.

Nature communications - 20 May 2021

Stoffel M A, Johnston S E, Pilkington J G, Pemberton J M

Abstract excerpt

Inbreeding depression is ubiquitous, but we still know little about its genetic architecture and precise effects in wild populations. Here, we combine long-term life-history data with 417 K imputed SNP genotypes for 5952 wild Soay sheep to explore inbreeding depression on a key fitness component, annual survival. Inbreeding manifests in long runs of homozygosity (ROH), which make up nearly half of the genome in...

Topics

Animals
Animals, Wild
Female
Genetic Fitness
Genetic Loci
Genome
Genome-Wide Association Study
Homozygote
Inbreeding
Inbreeding Depression
Male
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Population Dynamics

Scotland

Sheep

Source

Open in PubMed Open full text

Identifiers

PMID: 34016997
DOI: 10.1038/s41467-021-23222-9
PMCID: PMC8138023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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