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Article

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses

18 Jun 2025

Abstract excerpt

Abstract SARM1 has emerged as a promising therapeutic target in neurology due to its central role in axonal degeneration and its amenability to different modes of small molecule inhibition. One chemical approach to modulate SARM1 involves orthosteric inhibition via a SARM1-mediated base-exchange reaction between a small molecule and nicotinamide adenine dinucleotide (NAD + ), the substrate of SARM1, to generate...

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PMID: 42380289
DOI: 10.1038/s44386-025-00016-3

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