Article
Hierarchical distribution of somatic variants in newly diagnosed chronic myeloid leukaemia at diagnosis and early follow-up.
British journal of haematology - 1 Aug 2021
Romzova Marianna, Smitalova Dagmar, Hynst Jakub, Tom Nikola, Loja Tomas, Herudkova Zdenka, Jurcek Tomas, Stejskal Lukas, Zackova Daniela, Mayer Jiri, Racil Zdenek, Culen Martin
Abstract excerpt
There is an emerging body of evidence that patients with chronic myeloid leukaemia (CML) may carry not only breakpoint cluster region-Abelson murine leukaemia viral oncogene homologue 1 (BCR-ABL1) kinase domain mutations (BCR-ABL1 KD mutations), but also mutations in other genes. Their occurrence is highest during progression or at failure, but their impact at diagnosis is unclear. In the present study, we...
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