Article

Analysis of the transcriptome for novel therapeutic targets, and investigation of the role of APOBEC3B in chronic myeloid leukaemia stem cells

2018-01-01

Abstract excerpt

The introduction to the clinic of tyrosine kinase inhibitors (TKIs) for the treatment of chronic myeloid leukaemia (CML) revolutionized the outlook for patients. These drugs manage disease highly effectively in the majority of patients, through elimination of the bulk of the leukaemic cells from the blood and bone marrow. However, they fail to eradicate the underlying leukaemic stem cells (LSCs). Therefore, patien...

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Literature Corpus work: 43cf8467-c679-5493-af49-4164e245a401
DOI: 10.5525/gla.thesis.75031

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