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Article

The RNA sensor MDA5 detects SARS-CoV-2 infection

1 Jul 2021

Abstract excerpt

Human cells respond to infection by SARS-CoV-2, the virus that causes COVID-19, by producing cytokines including type I and III interferons (IFNs) and proinflammatory factors such as IL6 and TNF. IFNs can limit SARS-CoV-2 replication but cytokine imbalance contributes to severe COVID-19. We studied how cells detect SARS-CoV-2 infection. We report that the cytosolic RNA sensor MDA5 was required for type I and III...

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PMID: 34211037
DOI: 10.1038/s41598-021-92940-3

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