Article
Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jul 2021
Wei George Zhang, Martin Katherine A, Xing Peter Yuli, Agrawal Ruchi, Whiley Luke, Wood Thomas K, Hejndorf Sophia, Ng Yong Zhi, Low Jeremy Zhi Yan, Rossant Janet, Nechanitzky Robert, Holmes Elaine, Nicholson Jeremy K, Tan Eng-King, Matthews Paul M, Pettersson Sven
Abstract excerpt
While modulatory effects of gut microbes on neurological phenotypes have been reported, the mechanisms remain largely unknown. Here, we demonstrate that indole, a tryptophan metabolite produced by tryptophanase-expressing gut microbes, elicits neurogenic effects in the adult mouse hippocampus. Neurogenesis is reduced in germ-free (GF) mice and in GF mice monocolonized with a single-gene tnaA knockout (KO) mutant...
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