Article

Microbe-derived indole tunes organ-function and links microbe metabolites to biological ageing

2023-01-24

Abstract excerpt

To investigate the underlying molecular mechanisms on how the gut microbe metabolite, indoles, regulate host organ growth and function, germ-free male mice were mono-colonized with indole-producing wildtype Escherichia coli or tryptophanase-encoding tnaA knockout mutant indole-non-producing E. coli . The indole mutant E. coli recipient mice exhibited significant multiorgan decline and growth retardation combin...

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Literature Corpus work: 20007ea1-9bff-57bb-b7af-879405995a68
DOI: 10.1101/2023.01.24.525337

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