Article
Indoles from commensal bacteria extend healthspan.
Proceedings of the National Academy of Sciences of the United States of America - 5 Sept 2017
Sonowal Robert, Swimm Alyson, Sahoo Anusmita, Luo Liping, Matsunaga Yohei, Wu Ziqi, Bhingarde Jui A, Ejzak Elizabeth A, Ranawade Ayush, Qadota Hiroshi, Powell Domonica N, Capaldo Christopher T, Flacker Jonathan M, Jones Rhienallt M, Benian Guy M, Kalman Daniel
Abstract excerpt
Multiple studies have identified conserved genetic pathways and small molecules associated with extension of lifespan in diverse organisms. However, extending lifespan does not result in concomitant extension in healthspan, defined as the proportion of time that an animal remains healthy and free of age-related infirmities. Rather, mutations that extend lifespan often reduce healthspan and increase frailty. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.