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Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication

9 Nov 2017

Abstract excerpt

BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) structural protein Gag is necessary and sufficient to form viral particles. In addition to encoding the amino acid sequence for Gag, the underlying RNA sequence could encode cis-acting elements or nucleotide biases that are necessary for viral replication. Furthermore, RNA sequences that inhibit viral replication could be suppressed in gag. However, the...

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PMID: 29121951
DOI: 10.1186/s12977-017-0374-1

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