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Article

Modulation of Urate Transport by Drugs

17 Jun 2021

Abstract excerpt

BACKGROUND: Serum urate (SU) levels in primates are extraordinarily high among mammals. Urate is a Janus-faced molecule that acts physiologically as a protective antioxidant but provokes inflammation and gout when it precipitates at high concentrations. Transporters play crucial roles in urate disposition, and drugs that interact with urate transporters either by intention or by accident may modulate SU levels....

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PMID: 34204277
DOI: 10.3390/pharmaceutics13060899

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