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Article

Mutations of key driver genes in gastric cancer metastasis risk: a systematic review and meta-analysis.

Expert review of molecular diagnostics - 1 Sept 2021

Wang Jin, Shao Xinye, Liu Yang, Shi Ruichuan, Yang Bowen, Xiao Jiawen, Liu Yunpeng, Qu Xiujuan, Li Zhi

Abstract excerpt

Objective: Associations between gene mutations and metastasis in gastric cancer (GC) remain contradictory, resulting in the inaccurate estimation of the magnitude of the risk associated with specific genotypes.Methods: In this study, we first screened out four key driver genes (TP53, PIK3CA, APC and ARID1A) by jointly analyzing the mutation levels and searching the literature for genes associated with GC...

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PMID: 34196586
DOI: 10.1080/14737159.2021.1946394

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