Article
The Relationship Between Gene Mutations and the Clinicopathological Features and Prognosis of Gastric Cancer.
International journal of surgical pathology - 1 May 2024
Nie Zunzhen, Zeng Kaixuan, Yan Qingguo, Liu Yuangang, Bian Yawei, Zhu Jin, Guo Zhenzhen, He Furong, Shi Hai, Guo Ying
Abstract excerpt
Current treatments for gastric cancer (GC) are suboptimal. Potential therapeutic targets for GC were screened using next-generation sequencing. We examined many mutation genes linked to GC, including TP53 (60%), PIK3CA (19%), LRP1B (13%), and ERBB2 (12%), ARID1A (9%), KMT2C (9%), and KRAS (7%). The KMT2C, KRAS, CDK6, and ARID1A wild-type genes were dominant in diffuse-type GC (P < .05), but mutations did not...
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