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Article

Mutations of key driver genes in colorectal cancer progression and metastasis.

Cancer metastasis reviews - 1 Mar 2018

Huang Dongdong, Sun Wenjie, Zhou Yuwei, Li Peiwei, Chen Fang, Chen Hanwen, Xia Dajing, Xu Enping, Lai Maode, Wu Yihua, Zhang Honghe

Abstract excerpt

The association between mutations of key driver genes and colorectal cancer (CRC) metastasis has been investigated by many studies. However, the results of these studies have been contradictory. Here, we perform a comprehensive analysis to screen key driver genes from the TCGA database and validate the roles of these mutations in CRC metastasis. Using bioinformatics analysis, we identified six key driver genes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29322354
DOI: 10.1007/s10555-017-9726-5

Genes

KRAS
BRAF
SMAD4
APC

Provenance

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