Article
Integrated DNA and RNA sequencing reveals early drivers involved in metastasis of gastric cancer.
Cell death & disease - 21 Apr 2022
Zhang Jieyun, Liu Fatao, Yang Yanan, Yu Nuoya, Weng Xiaoling, Yang Yue, Gong Zhe, Huang Shenglin, Gan Lu, Sun Sijie, Zhang Xiaowei, Gong Yiwei, Liu Yun, Guo Weijian
Abstract excerpt
Gastric cancer (GC) is the second cause of cancer-related death and metastasis is an important cause of death. Considering difficulties in searching for metastatic driver mutations, we tried a novel strategy here. We conducted an integrative genomic analysis on GC and identified early drivers lead to metastasis. Whole-exome sequencing (WES), transcriptomes sequencing and targeted-exome sequencing (TES) were...
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