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High-Throughput Screening to Identify Inhibitors of Plasmodium falciparum Importin α

2 Apr 2022

Abstract excerpt

The global burden of malaria and toxoplasmosis has been limited by the use of efficacious anti-parasitic agents, however, emerging resistance in Plasmodium species and Toxoplasma gondii threatens disease control worldwide, implying that new agents/therapeutic targets are urgently needed. Nuclear localization signal (NLS)-dependent transport into the nucleus, mediated by members of the importin (IMP) superfamily...

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PMID: 35406765
DOI: 10.3390/cells11071201

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