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Article

Drosophila tubulin polymerization promoting protein mutants reveal pathological correlates relevant to human Parkinson's disease.

Scientific reports - 30 Jun 2021

Xie Jing, Chen Shuting, Bopassa Jean C, Banerjee Swati

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative disorder with no known cure. PD is characterized by locomotion deficits, nigrostriatal dopaminergic neuronal loss, mitochondrial dysfunctions and formation of α-Synuclein aggregates. A well-conserved and less understood family of Tubulin Polymerization Promoting Proteins (TPPP) is also implicated in PD and related disorders, where TPPP exists in...

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Identifiers

PMID: 34193896
DOI: 10.1038/s41598-021-92738-3
PMCID: PMC8245532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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